Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 2
Ligand
BDBM50336818
Substrate
n/a
Meas. Tech.
ChEMBL_718679 (CHEMBL1680830)
IC50
250±n/a nM
Citation
Miyamoto, Y; Banno, Y; Yamashita, T; Fujimoto, T; Oi, S; Moritoh, Y; Asakawa, T; Kataoka, O; Yashiro, H; Takeuchi, K; Suzuki, N; Ikedo, K; Kosaka, T; Tsubotani, S; Tani, A; Sasaki, M; Funami, M; Amano, M; Yamamoto, Y; Aertgeerts, K; Yano, J; Maezaki, H Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. J Med Chem 54:831-50 (2012) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 2
Synonyms:
DPP2_RAT | Dipeptidyl peptidase II | Dpp2 | Dpp7
Type:
PROTEIN
Mol. Mass.:
55100.60
Organism:
Rattus norvegicus
Description:
ChEMBL_718679
Residue:
500
Sequence:
MGLHPCSPVDHGVPSWVLVLLLTLGLCSLQATADSVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSLANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRHNLGVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTNFLGPLPANPVKVGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSCADPTGCGTGSNARAWDYQACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRPDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLEATLIREWVAAARLKQPAEAQWPGPK
Inhibitor
Name:
BDBM50336818
Synonyms:
5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-(4-methylphenyl)pyridine-3-carboxylic Acid Dihydrochloride | CHEMBL1672125
Type:
Small organic molecule
Emp. Form.:
C26H30N2O2
Mol. Mass.:
402.5286
SMILES:
Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O