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TargetExtracellular signal-regulated kinase 5 (ERK5)
LigandBDBM50337135
Substrate/Competitorn/a
Meas. Tech.ChEMBL_719091
IC50 310±n/a nM
Citation Deng, XYang, QKwiatkowski, NSim, TMcDermott, USettleman, JELee, JDGray, NS Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1. ACS Med Chem Lett2:195-200 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Extracellular signal-regulated kinase 5 (ERK5)
Name:Extracellular signal-regulated kinase 5 (ERK5)
Synonyms:Big MAP kinase 1 | ERK5 | Mitogen-activated protein kinase 7
Type:Protein
Mol. Mass.:88377.36
Organism:Homo sapiens (Human)
Description:Q13164
Residue:816
Sequence:
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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BDBM50337135
NameBDBM50337135
Synonyms:4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)benzenesulfonamide | Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 6 | CHEMBL1673047
TypeSmall organic molecule
Emp. Form.C19H18N6O3S
Mol. Mass.410.45
SMILESCN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc12
Structure
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n/a