Reaction Details Report a problem with these data
Target
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Ligand
BDBM50168995
Substrate
n/a
Meas. Tech.
ChEMBL_736246 (CHEMBL1693390)
Ki
3±n/a nM
Citation
 Poláková, M; Šeták, S; Lattová, E; Petruš, L; Mucha, J; Tvaroška, I; Kóna, J a-D-mannose derivatives as models designed for selective inhibition of Golgia-mannosidase II. Eur J Med Chem 46:944-52 (2011) [PubMed]  Article 
Target
Name:
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Synonyms:
MA1A1_DROME | Man(9)-alpha-mannosidase | Mannosidase-1 | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B | alpha-Man-Ia | alpha-man-1 | mas-1
Type:
PROTEIN
Mol. Mass.:
74961.37
Organism:
Drosophila melanogaster
Description:
ChEMBL_103952
Residue:
667
Sequence:
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
  
Inhibitor
Name:
BDBM50168995
Synonyms:
(-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indolizine-1,2,8-triol | 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL | CHEMBL371197 | SWAINSONINE
Type:
Small organic molecule
Emp. Form.:
C8H15NO3
Mol. Mass.:
173.2096
SMILES:
O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: