Target
Calmodulin-domain protein kinase 1
Ligand
BDBM50345712
Substrate
n/a
Meas. Tech.
ChEMBL_750529 (CHEMBL1786290)
IC50
15±n/a nM
Citation
 Murphy, RCOjo, KKLarson, ETCastellanos-Gonzalez, APerera, BGKeyloun, KRKim, JEBhandari, JGMuller, NRVerlinde, CLWhite, ACMerritt, EAVan Voorhis, WCMaly, DJ Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett 1:331-335 (2011) [PubMed]  Article 
Target
Name:
Calmodulin-domain protein kinase 1
Synonyms:
Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57248.42
Organism:
Toxoplasma gondii
Description:
n/a
Residue:
507
Sequence:
MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLLKLCGN
  
Inhibitor
Name:
BDBM50345712
Synonyms:
3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1231372 | CHEMBL2069314 | US10544104, Compound 5h | US11247972, Compound 5h | US9765037, Compound 5h
Type:
Small organic molecule
Emp. Form.:
C22H24N6
Mol. Mass.:
372.4662
SMILES:
Nc1ncnc2n(CC3CCNCC3)nc(Cc3cccc4ccccc34)c12
Structure:
Search PDB for entries with ligand similarity: