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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50350294
Substrate
n/a
Meas. Tech.
ChEMBL_761927 (CHEMBL1817446)
IC50
3000±n/a nM
Citation
 Dolusic, E; Larrieu, P; Moineaux, L; Stroobant, V; Pilotte, L; Colau, D; Pochet, L; Van den Eynde, B; Masereel, B; Wouters, J; Frédérick, R Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J Med Chem 54:5320-34 (2011) [PubMed]  Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47757.90
Organism:
Mus musculus
Description:
ChEMBL_1452150
Residue:
406
Sequence:
MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM50350294
Synonyms:
CHEMBL1812540
Type:
Small organic molecule
Emp. Form.:
C16H11FN2O2
Mol. Mass.:
282.2691
SMILES:
[O-][N+](=O)c1cccc(\C=C\c2c[nH]c3cc(F)ccc23)c1
Structure:
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