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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50350295
Substrate
n/a
Meas. Tech.
ChEMBL_761927 (CHEMBL1817446)
IC50
>80000±n/a nM
Citation
 Dolusic, E; Larrieu, P; Moineaux, L; Stroobant, V; Pilotte, L; Colau, D; Pochet, L; Van den Eynde, B; Masereel, B; Wouters, J; Frédérick, R Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J Med Chem 54:5320-34 (2011) [PubMed]  Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47757.90
Organism:
Mus musculus
Description:
ChEMBL_1452150
Residue:
406
Sequence:
MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM50350295
Synonyms:
CHEMBL1812542
Type:
Small organic molecule
Emp. Form.:
C11H8N2
Mol. Mass.:
168.1946
SMILES:
N#C\C=C/c1c[nH]c2ccccc12
Structure:
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