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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50379177
Substrate
n/a
Meas. Tech.
ChEMBL_810396 (CHEMBL2016217)
EC50
489±n/a nM
Citation
 Brocklehurst, KJ; Broo, A; Butlin, RJ; Brown, HS; Clarke, DS; Davidsson, Ö; Goldberg, K; Groombridge, SD; Kelly, EE; Leach, A; McKerrecher, D; O'Donnell, C; Poucher, S; Schofield, P; Scott, JS; Teague, J; Westgate, L; Wood, MJ Discovery, optimisation and in vivo evaluation of novel GPR119 agonists. Bioorg Med Chem Lett 21:7310-6 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50379177
Synonyms:
CHEMBL2010834
Type:
Small organic molecule
Emp. Form.:
C24H28F3N3O2
Mol. Mass.:
447.4932
SMILES:
CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1
Structure:
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