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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50379221
Substrate
n/a
Meas. Tech.
ChEMBL_811222 (CHEMBL2015057)
IC50
>100000±n/a nM
Citation
 Abu Thaher, B; Arnsmann, M; Totzke, F; Ehlert, JE; Kubbutat, MH; Schächtele, C; Zimmermann, MO; Koch, P; Boeckler, FM; Laufer, SA Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases. J Med Chem 55:961-5 (2012) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50379221
Synonyms:
CHEMBL2011300 | US9416123, 15
Type:
Small organic molecule
Emp. Form.:
C17H13Cl3N4O2
Mol. Mass.:
411.67
SMILES:
CCOC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl |(15.66,-51.66,;16.99,-52.43,;18.32,-51.66,;19.66,-52.43,;19.66,-53.97,;20.99,-51.66,;22.46,-52.13,;22.93,-53.6,;23.37,-50.89,;22.46,-49.64,;20.99,-50.12,;19.75,-49.21,;19.73,-47.68,;18.38,-46.92,;17.06,-47.71,;17.08,-49.26,;18.43,-50,;24.91,-50.89,;25.67,-49.57,;24.89,-48.23,;27.2,-49.56,;27.98,-50.9,;29.52,-50.9,;27.21,-52.23,;25.67,-52.23,;24.9,-53.56,)|
Structure:
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