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Target
Monoglyceride lipase
Ligand
BDBM50379241
Substrate
n/a
Meas. Tech.
ChEMBL_811245 (CHEMBL2015197)
Ki
40000±n/a nM
Citation
 Cisneros, JA; Björklund, E; González-Gil, I; Hu, Y; Canales, A; Medrano, FJ; Romero, A; Ortega-Gutiérrez, S; Fowler, CJ; López-Rodríguez, ML Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors. J Med Chem 55:824-36 (2012) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50379241
Synonyms:
CHEMBL2011479
Type:
Small organic molecule
Emp. Form.:
C18H18O3
Mol. Mass.:
282.3337
SMILES:
O=C(Cc1ccc(Cc2ccccc2)cc1)OC[C@H]1CO1 |r|
Structure:
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