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Target
Serine/threonine-protein kinase haspin
Ligand
BDBM50379520
Substrate
n/a
Meas. Tech.
ChEMBL_812377 (CHEMBL2014113)
IC50
470±n/a nM
Citation
 Cuny, GD; Ulyanova, NP; Patnaik, D; Liu, JF; Lin, X; Auerbach, K; Ray, SS; Xian, J; Glicksman, MA; Stein, RL; Higgins, JM Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett 22:2015-9 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase haspin
Synonyms:
GSG2 | Germ cell-specific gene 2 protein | H-haspin | HASPIN | HASP_HUMAN | Haploid germ cell-specific nuclear protein kinase
Type:
PROTEIN
Mol. Mass.:
88531.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510616
Residue:
798
Sequence:
MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
  
Inhibitor
Name:
BDBM50379520
Synonyms:
CHEMBL2012573
Type:
Small organic molecule
Emp. Form.:
C19H25N3O
Mol. Mass.:
311.4213
SMILES:
COc1ccc2c(c1)n(CCCCN(C)C)c1c(C)nccc21
Structure:
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