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TargetLow molecular weight phosphotyrosine protein phosphatase (LMWPTP)
LigandBDBM50379825
Substrate/Competitorn/a
Meas. Tech.ChEMBL_809716
IC50 4000±n/a nM
Citation Ottanà, RMaccari, RAmuso, SWolber, GSchuster, DHerdlinger, SManao, GCamici, GPaoli, P New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells. Eur J Med Chem50:332-43 (2012) [PubMed]  Article
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Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)
Name:Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)
Synonyms:ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | Low molecular weight phosphotyrosine protein phosphatase | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:n/a
Mol. Mass.:18042.81
Organism:Homo sapiens (Human)
Description:P24666
Residue:158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
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BDBM50379825
NameBDBM50379825
Synonyms:CHEMBL2011701
TypeSmall organic molecule
Emp. Form.C32H23F3N2O4S
Mol. Mass.588.596
SMILESOC(=O)c1ccc(CN2C(=O)\C(S\C2=N/c2ccc(cc2)C(F)(F)F)=C\c2ccc(OCc3ccccc3)cc2)cc1
Structure
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