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Target
Galactokinase
Ligand
BDBM50380333
Substrate
n/a
Meas. Tech.
ChEMBL_813856 (CHEMBL2020225)
IC50
1800±n/a nM
Citation
 Odejinmi, S; Rascon, R; Tang, M; Vankayalapati, H; Lai, K Structure-activity analysis and cell-based optimization of human galactokinase inhibitors. ACS Med Chem Lett 2:667-672 (2011) [PubMed]  Article 
Target
Name:
Galactokinase
Synonyms:
GALK | GALK1 | GALK1_HUMAN | Galactokinase | Galactokinase (GALK) | Galactose kinase
Type:
Enzyme
Mol. Mass.:
42271.26
Organism:
Homo sapiens (Human)
Description:
P51570
Residue:
392
Sequence:
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
  
Inhibitor
Name:
BDBM50380333
Synonyms:
CHEMBL2017794
Type:
Small organic molecule
Emp. Form.:
C18H14N2O2S2
Mol. Mass.:
354.446
SMILES:
Oc1ccc(cc1)C1NC(=O)C(C#N)=C(SCc2ccccc2)S1 |t:14|
Structure:
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