Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50380798
Substrate
n/a
Meas. Tech.
ChEMBL_813619 (CHEMBL2019768)
IC50
60±n/a nM
Citation
 Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22:2784-8 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50380798
Synonyms:
CHEMBL2018031
Type:
Small organic molecule
Emp. Form.:
C26H28N6O4
Mol. Mass.:
488.5383
SMILES:
Nc1ncc(nc1C(=O)N[C@H]1C2CC3CC1C[C@@](O)(C3)C2)-c1cccc(c1)-c1cnn(CC(O)=O)c1 |r,wU:10.10,17.19,TLB:14:15:20:12.13.19,14:13:10.15.16:20,18:17:10:12.14.13,THB:19:13:10:16.17.20,19:17:10:12.14.13,9:10:12.14.13:16.17.20,9:10:20:12.13.19,(-.81,-6.94,;-.87,-5.4,;-2.24,-4.68,;-2.3,-3.15,;-.99,-2.33,;.37,-3.04,;.43,-4.58,;1.8,-5.29,;1.86,-6.83,;3.1,-4.46,;4.46,-5.17,;5.63,-3.87,;6.97,-4.33,;8.36,-3.95,;7.37,-5.25,;5.96,-4.72,;5.92,-3.14,;6.93,-1.88,;6.92,-.33,;8.34,-2.42,;5.59,-2.39,;-1.05,-.79,;.26,.03,;.2,1.57,;-1.16,2.29,;-2.47,1.47,;-2.41,-.07,;-3.74,2.34,;-5.2,1.86,;-6.12,3.1,;-5.21,4.35,;-6.02,5.67,;-7.56,5.63,;-8.36,6.94,;-8.29,4.28,;-3.75,3.88,)|
Structure:
Search PDB for entries with ligand similarity: