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Target
Mu-type opioid receptor
Ligand
BDBM50381027
Substrate
n/a
Meas. Tech.
ChEMBL_814124 (CHEMBL2020765)
Ki
35±n/a nM
Citation
 Nagase, H; Akiyama, J; Nakajima, R; Hirayama, S; Nemoto, T; Gouda, H; Hirono, S; Fujii, H Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. Bioorg Med Chem Lett 22:2775-9 (2012) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50381027
Synonyms:
CHEMBL2017142
Type:
Small organic molecule
Emp. Form.:
C28H34N2O3
Mol. Mass.:
446.5812
SMILES:
CN([C@H]1CCC23Cc4ccc(O)cc4C2(CCN(CC2CC2)C3)C1)C(=O)\C=C\c1ccoc1 |r|
Structure:
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