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Target
Aurora kinase B
Ligand
BDBM50381719
Substrate
n/a
Meas. Tech.
ChEMBL_816379 (CHEMBL2024777)
IC50
1±n/a nM
Citation
 Curtin, ML; Frey, RR; Heyman, HR; Soni, NB; Marcotte, PA; Pease, LJ; Glaser, KB; Magoc, TJ; Tapang, P; Albert, DH; Osterling, DJ; Olson, AM; Bouska, JJ; Guan, Z; Preusser, LC; Polakowski, JS; Stewart, KD; Tse, C; Davidsen, SK; Michaelides, MR Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families. Bioorg Med Chem Lett 22:3208-12 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50381719
Synonyms:
CHEMBL2022856
Type:
Small organic molecule
Emp. Form.:
C26H23FN6O2S
Mol. Mass.:
502.563
SMILES:
C[C@@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(F)c2)cc1 |r|
Structure:
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