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Target
D(3) dopamine receptor
Ligand
BDBM50382295
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
3.3±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382295
Synonyms:
CHEMBL2024507
Type:
Small organic molecule
Emp. Form.:
C23H33F3N2O
Mol. Mass.:
410.5161
SMILES:
CC(=O)N[C@H]1CC[C@H](CCN2CCC(Cc3cccc(c3)C(F)(F)F)CC2)CC1 |r,wU:4.3,wD:7.7,(4.59,-14.97,;5.92,-14.2,;5.88,-12.66,;7.25,-14.97,;8.59,-14.19,;8.59,-12.65,;9.92,-11.88,;11.24,-12.65,;12.58,-11.89,;13.91,-12.66,;15.25,-11.9,;16.57,-12.68,;17.91,-11.92,;17.92,-10.38,;19.26,-9.61,;20.59,-10.39,;21.92,-9.63,;23.25,-10.41,;23.25,-11.94,;21.92,-12.71,;20.58,-11.93,;21.92,-14.25,;20.58,-15.02,;23.25,-15.02,;21.93,-15.8,;16.59,-9.6,;15.24,-10.36,;11.24,-14.19,;9.92,-14.96,)|
Structure:
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