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Target
D(3) dopamine receptor
Ligand
BDBM50382297
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
11±n/a nM
Citation
 Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382297
Synonyms:
CHEMBL2024511
Type:
Small organic molecule
Emp. Form.:
C21H32F3N3O2S
Mol. Mass.:
447.558
SMILES:
CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)CC1 |r,wU:5.4,wD:8.8,(-11.08,-24.94,;-9.74,-24.17,;-8.97,-22.83,;-10.51,-22.84,;-8.41,-24.94,;-7.08,-24.17,;-7.08,-22.63,;-5.75,-21.85,;-4.42,-22.63,;-3.08,-21.86,;-1.75,-22.63,;-.42,-21.87,;.91,-22.65,;2.24,-21.89,;2.25,-20.35,;3.59,-19.59,;4.92,-20.36,;6.26,-19.6,;7.59,-20.38,;7.58,-21.91,;6.25,-22.68,;4.91,-21.91,;6.25,-24.22,;4.92,-24.99,;7.59,-24.99,;6.27,-25.77,;.92,-19.57,;-.42,-20.33,;-4.42,-24.17,;-5.75,-24.93,)|
Structure:
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