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TargetDopamine D2 receptor/Serotonin 2 (5-HT2) receptor
LigandBDBM50382309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_816864
Ki 106±n/a nM
Citation Agai-Csongor, EDomány, GNógrádi, KGalambos, JVágó, IKeseru, GMGreiner, ILaszlovszky, IGere, ASchmidt, EKiss, BVastag, MTihanyi, KSághy, KLaszy, JGyertyán, IZájer-Balázs, MGémesi, LKapás, MSzombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett22:3437-40 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DOPAMINE D2/D4 | DRD2 | Dopamine D2 receptor | Dopamine2-like
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:50931.60
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat striatal membranes.
Residue:444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382309
NameBDBM50382309
Synonyms:CHEMBL2024525
TypeSmall organic molecule
Emp. Form.C21H32Cl2N4O
Mol. Mass.427.411
SMILESCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccc(Cl)cc2Cl)CC1 |r,wU:6.5,wD:9.9,(3.15,-13.27,;4.48,-14.04,;4.48,-15.58,;5.81,-13.27,;5.81,-11.73,;7.15,-14.04,;8.48,-13.27,;8.48,-11.73,;9.81,-10.95,;11.14,-11.73,;12.47,-10.96,;13.8,-11.74,;15.14,-10.97,;16.46,-11.75,;17.8,-10.99,;17.81,-9.45,;16.48,-8.67,;15.13,-9.43,;19.15,-8.69,;19.15,-7.16,;20.49,-6.39,;21.82,-7.17,;23.16,-6.41,;21.81,-8.71,;20.48,-9.47,;20.46,-11.01,;11.14,-13.27,;9.81,-14.03,)|
Structure
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