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Target
Acylamino-acid-releasing enzyme
Ligand
BDBM50382729
Substrate
n/a
Meas. Tech.
ChEMBL_817870 (CHEMBL2027518)
IC50
98000±n/a nM
Citation
 Sandomenico, A; Russo, A; Palmieri, G; Bergamo, P; Gogliettino, M; Falcigno, L; Ruvo, M Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation. J Med Chem 55:2102-11 (2012) [PubMed]  Article 
Target
Name:
Acylamino-acid-releasing enzyme
Synonyms:
AARE | ACPH_PIG | APEH | APH | Acyl-peptide hydrolase | Acylaminoacyl-peptidase
Type:
PROTEIN
Mol. Mass.:
81230.60
Organism:
Sus scrofa
Description:
ChEMBL_817870
Residue:
732
Sequence:
MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGRYRTVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGTAEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVADKKRPKAESFFQTKALDVTGSDDEMARTKKPDQAIKGDQFLFYEDWGENMVSKSTPVLCVLDIESGNISVLEGVPESVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLTGGKCELLSDESVAVTSPRLSPDQCRIVYLRFPSLVPHQQCGQLCLYDWYTRVTSVVVDIVPRQLGEDFSGIYCSLLPLGCWSADSQRVVFDSPQRSRQDLFAVDTQMGSVTSLTAGGSGGSWKLLTIDRDLMVVQFSTPSVPPSLKVGFLPPAGKEQAVSWVSLEEAEPFPDISWSIRVLQPPPQQEHVQYAGLDFEAILLQPSNSPEKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDAGRVALMGGSHGGFLSCHLIGQYPETYSACVVRNPVINIASMMGSTDIPDWCMVEAGFSYSSDCLPDLSVWAAMLDKSPIKYAPQVKTPLLLMLGQEDRRVPFKQGMEYYRVLKARNVPVRLLLYPKSTHALSEVEVESDSFMNAVLWLCTHLGS
  
Inhibitor
Name:
BDBM50382729
Synonyms:
CHEMBL2023560
Type:
Small organic molecule
Emp. Form.:
C24H36F3N7O5S
Mol. Mass.:
591.647
SMILES:
CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)C(F)(F)F)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O |r|
Structure:
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