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TargetAcylamino-acid-releasing enzyme
LigandBDBM50382729
Substrate/Competitorn/a
Meas. Tech.ChEMBL_817870
Ki 24000±n/a nM
Citation Sandomenico, ARusso, APalmieri, GBergamo, PGogliettino, MFalcigno, LRuvo, M Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation. J Med Chem55:2102-11 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acylamino-acid-releasing enzyme
Name:Acylamino-acid-releasing enzyme
Synonyms:AARE | APEH | APH | Acyl-peptide hydrolase | Acylaminoacyl-peptidase
Type:PROTEIN
Mol. Mass.:81230.60
Organism:Sus scrofa
Description:ChEMBL_817870
Residue:732
Sequence:
MERQVLLSEPEEAAALYRGLSRQPALSAACLGPEVTTQYGGRYRTVHTEWTQRDLERMEN
IRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTGTAEEKQF
LEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVADKKRPKAESFFQTK
ALDVTGSDDEMARTKKPDQAIKGDQFLFYEDWGENMVSKSTPVLCVLDIESGNISVLEGV
PESVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRFCTNRRSALYYVDLTGGKCELLSDESV
AVTSPRLSPDQCRIVYLRFPSLVPHQQCGQLCLYDWYTRVTSVVVDIVPRQLGEDFSGIY
CSLLPLGCWSADSQRVVFDSPQRSRQDLFAVDTQMGSVTSLTAGGSGGSWKLLTIDRDLM
VVQFSTPSVPPSLKVGFLPPAGKEQAVSWVSLEEAEPFPDISWSIRVLQPPPQQEHVQYA
GLDFEAILLQPSNSPEKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGS
TGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDAGRVALMGGSHGGFLSCHLIGQY
PETYSACVVRNPVINIASMMGSTDIPDWCMVEAGFSYSSDCLPDLSVWAAMLDKSPIKYA
PQVKTPLLLMLGQEDRRVPFKQGMEYYRVLKARNVPVRLLLYPKSTHALSEVEVESDSFM
NAVLWLCTHLGS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382729
NameBDBM50382729
Synonyms:CHEMBL2023560
TypeSmall organic molecule
Emp. Form.C24H36F3N7O5S
Mol. Mass.591.647
SMILESCSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)C(F)(F)F)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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