Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM50383012
Substrate
n/a
Meas. Tech.
ChEMBL_818439 (CHEMBL2034759)
IC50
>1000000±n/a nM
Citation
 Woon, EC; Demetriades, M; Bagg, EA; Aik, W; Krylova, SM; Ma, JH; Chan, M; Walport, LJ; Wegman, DW; Dack, KN; McDonough, MA; Krylov, SN; Schofield, CJ Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. J Med Chem 55:2173-84 (2012) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50383012
Synonyms:
CHEMBL2030872
Type:
Small organic molecule
Emp. Form.:
C16H15NO5S
Mol. Mass.:
333.359
SMILES:
OC(=O)[C@H](CSCc1ccc2ccccc2c1)NC(=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: