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Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM50383670
Substrate
n/a
Meas. Tech.
ChEMBL_819010 (CHEMBL2034242)
EC50
>3000±n/a nM
Citation
 Noel, R; Song, X; Shin, Y; Banerjee, S; Kojetin, D; Lin, L; Ruiz, CH; Cameron, MD; Burris, TP; Kamenecka, TM Synthesis and SAR of tetrahydroisoquinolines as Rev-erba agonists. Bioorg Med Chem Lett 22:3739-42 (2012) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM50383670
Synonyms:
CHEMBL2030069
Type:
Small organic molecule
Emp. Form.:
C28H26N2O
Mol. Mass.:
406.5188
SMILES:
O=C(N1Cc2ccccc2CC1CNCc1ccccc1)c1cccc2ccccc12
Structure:
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