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Target
Peptide deformylase
Ligand
BDBM50383986
Substrate
n/a
Meas. Tech.
ChEMBL_819737 (CHEMBL2034167)
IC50
0.51±n/a nM
Citation
 Axten, JM; Medina, JR; Blackledge, CW; Duquenne, C; Grant, SW; Bobko, MA; Peng, T; Miller, WH; Pinckney, T; Gallagher, TF; Kulkarni, S; Lewandowski, T; Van Aller, GS; Zonis, R; Ward, P; Campobasso, N Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Bioorg Med Chem Lett 22:4028-32 (2012) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STRPN | PDF | Polypeptide deformylase | def
Type:
PROTEIN
Mol. Mass.:
22668.24
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_819737
Residue:
203
Sequence:
MSAIERITKAAHLIDMNDIIREGNPTLRAIAEEVTFPLSDQEIILGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
  
Inhibitor
Name:
BDBM50383986
Synonyms:
CHEMBL2032124
Type:
Small organic molecule
Emp. Form.:
C20H31N3O6
Mol. Mass.:
409.4766
SMILES:
ON(C[C@@H](CC1CCCC1)C(=O)N1CCC[C@H]1C(=O)NC(=O)OC1CCC1)C=O |r|
Structure:
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