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Target
Neutrophil elastase
Ligand
BDBM50384112
Substrate
n/a
Meas. Tech.
ChEMBL_819860 (CHEMBL2034574)
IC50
2600±n/a nM
Citation
 Santana, AB; Lucas, SD; Gonçalves, LM; Correia, HF; Cardote, TA; Guedes, RC; Iley, J; Moreira, R N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett 22:3993-7 (2012) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50384112
Synonyms:
CHEMBL2029557
Type:
Small organic molecule
Emp. Form.:
C12H13NO5S
Mol. Mass.:
283.3
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C(=O)OC(C)(C)C1=O
Structure:
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