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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50384378
Substrate
n/a
Meas. Tech.
ChEMBL_818323 (CHEMBL2034460)
IC50
15.14±n/a nM
Citation
 Brown, DS; Cumming, JG; Bethel, P; Finlayson, J; Gerhardt, S; Nash, I; Pauptit, RA; Pike, KG; Reid, A; Snelson, W; Swallow, S; Thompson, C The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38a MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett 22:3879-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50384378
Synonyms:
CHEMBL2031222
Type:
Small organic molecule
Emp. Form.:
C27H27N5O2
Mol. Mass.:
453.5356
SMILES:
CN1CCN(CC1)c1ccc2ncn(-c3cc(NC(=O)c4ccccc4)ccc3C)c(=O)c2c1
Structure:
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