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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50384521
Substrate
n/a
Meas. Tech.
ChEMBL_821912 (CHEMBL2039558)
IC50
1±n/a nM
Citation
 Kim, SH; Bok, JH; Lee, JH; Kim, IH; Kwon, SW; Lee, GB; Kang, SK; Park, JS; Jung, WH; Kim, HY; Rhee, SD; Ahn, SH; Bae, MA; Ha, DC; Kim, KY; Ahn, JH Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. ACS Med Chem Lett 3:88-93 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50384521
Synonyms:
CHEMBL2036233
Type:
Small organic molecule
Emp. Form.:
C23H29Cl3N4O4S
Mol. Mass.:
563.925
SMILES:
CC1CCN(c2c(Cl)cc(Cl)cc2Cl)S(=O)(=O)N1CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O |r,wU:22.23,wD:29.36,TLB:31:29:26:24.23.22,21:22:30.29.28:26,32:29:26:24.23.22,22:23:30:28.27.26,THB:31:23:30.29.28:26,22:27:30:24.31.23,(13.06,-7.03,;11.73,-7.79,;10.39,-7.01,;9.05,-7.79,;9.05,-9.34,;7.72,-10.11,;6.39,-9.35,;6.39,-7.81,;5.05,-10.12,;5.06,-11.67,;3.73,-12.44,;6.4,-12.43,;7.72,-11.65,;9.05,-12.42,;10.38,-10.1,;11.15,-11.44,;9.6,-11.44,;11.73,-9.34,;13.06,-10.12,;14.39,-9.35,;14.4,-7.81,;15.73,-10.13,;15.72,-11.67,;17.09,-12.34,;16.8,-13.75,;15.78,-14.73,;14.44,-14.1,;14.59,-12.67,;15.26,-14.15,;16.69,-14.83,;16.42,-16.36,;17.81,-13.8,;18.17,-15.23,;18.57,-16.72,;19.27,-14.15,)|
Structure:
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