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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50384524
Substrate
n/a
Meas. Tech.
ChEMBL_821912 (CHEMBL2039558)
IC50
5±n/a nM
Citation
 Kim, SH; Bok, JH; Lee, JH; Kim, IH; Kwon, SW; Lee, GB; Kang, SK; Park, JS; Jung, WH; Kim, HY; Rhee, SD; Ahn, SH; Bae, MA; Ha, DC; Kim, KY; Ahn, JH Synthesis and biological evaluation of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors. ACS Med Chem Lett 3:88-93 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50384524
Synonyms:
CHEMBL2036236
Type:
Small organic molecule
Emp. Form.:
C24H29Cl3N4O4S
Mol. Mass.:
575.935
SMILES:
NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CC4(CC4)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 |r,wU:9.10,wD:3.2,TLB:10:9:4.3.35:34,8:3:34:6.7.9,1:3:34:6.7.9,THB:9:7:4:35.33.34,9:33:4:6.8.7,8:7:4.3.35:34,(18.57,-17.37,;18.17,-15.89,;19.27,-14.8,;16.69,-15.48,;16.42,-17.02,;15.79,-15.38,;16.8,-14.41,;17.09,-12.99,;17.81,-14.46,;15.72,-12.32,;15.73,-10.78,;14.39,-10,;14.4,-8.46,;13.06,-10.77,;11.73,-9.99,;11.73,-8.45,;10.38,-7.66,;9.61,-6.32,;11.15,-6.32,;9.05,-8.45,;9.05,-9.99,;7.72,-10.77,;6.39,-10,;6.39,-8.46,;5.05,-10.77,;5.06,-12.32,;3.73,-13.1,;6.4,-13.08,;7.72,-12.3,;9.05,-13.07,;10.38,-10.76,;11.15,-12.09,;9.6,-12.09,;14.59,-13.33,;14.44,-14.75,;15.26,-14.81,)|
Structure:
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