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TargetTyrosine-protein kinase receptor TYRO3
LigandBDBM50384579
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820661
IC50 80±n/a nM
Citation Liu, JYang, CSimpson, CDeryckere, DVan Deusen, AMiley, MJKireev, DNorris-Drouin, JSather, SHunter, DKorboukh, VKPatel, HSJanzen, WPMachius, MJohnson, GLEarp, HSGraham, DKFrye, SVWang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase receptor TYRO3
Name:Tyrosine-protein kinase receptor TYRO3
Synonyms:TYRO3 | Tyrosine-protein kinase SKY | Tyrosine-protein kinase receptor TYRO3
Type:Protein
Mol. Mass.:96894.13
Organism:Homo sapiens (Human)
Description:Q06418
Residue:890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
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  Blast E-value cutoff:
BDBM50384579
NameBDBM50384579
Synonyms:CHEMBL2036794 | US9744172, Compound UNC00000343A
TypeSmall organic molecule
Emp. Form.C21H28N6
Mol. Mass.364.4872
SMILESCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1 |(4.32,-43.39,;5.65,-44.16,;5.65,-45.7,;6.98,-46.48,;8.32,-45.71,;8.32,-44.16,;9.65,-43.39,;10.98,-44.16,;12.46,-43.68,;13.37,-44.93,;12.46,-46.19,;12.94,-47.65,;11.91,-48.79,;10.4,-48.46,;9.37,-49.6,;9.84,-51.07,;8.8,-52.21,;11.34,-51.39,;12.38,-50.25,;10.98,-45.71,;9.65,-46.48,;12.93,-42.21,;14.44,-41.89,;14.92,-40.43,;13.89,-39.29,;12.37,-39.61,;11.91,-41.08,)|
Structure
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