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TargetTyrosine-protein kinase receptor UFO
LigandBDBM50384593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820660
IC50 370±n/a nM
Citation Liu, JYang, CSimpson, CDeryckere, DVan Deusen, AMiley, MJKireev, DNorris-Drouin, JSather, SHunter, DKorboukh, VKPatel, HSJanzen, WPMachius, MJohnson, GLEarp, HSGraham, DKFrye, SVWang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase receptor UFO
Name:Tyrosine-protein kinase receptor UFO
Synonyms:2.7.10.1 | AXL | AXL oncogene | Tyrosine-protein kinase receptor UFO (AXL) | UFO
Type:Enzyme
Mol. Mass.:98316.99
Organism:Homo sapiens (Human)
Description:P30530
Residue:894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384593
NameBDBM50384593
Synonyms:CHEMBL2036629
TypeSmall organic molecule
Emp. Form.C19H24N6
Mol. Mass.336.4341
SMILESCNc1ncc2c(nn(C[C@@H]3CC[C@H](N)CC3)c2n1)-c1ccccc1 |r,wU:10.9,13.13,(15.74,-11.88,;17.07,-12.65,;18.41,-11.88,;18.41,-10.33,;19.74,-9.56,;21.07,-10.33,;22.55,-9.85,;23.46,-11.1,;22.55,-12.36,;23.02,-13.82,;21.99,-14.96,;20.49,-14.63,;19.46,-15.77,;19.93,-17.24,;18.89,-18.38,;21.43,-17.56,;22.47,-16.42,;21.07,-11.88,;19.74,-12.65,;23.02,-8.38,;24.53,-8.07,;25.01,-6.6,;23.97,-5.46,;22.46,-5.79,;21.99,-7.25,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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