Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM50384605
Substrate
n/a
Meas. Tech.
ChEMBL_820660 (CHEMBL2037931)
IC50
360±n/a nM
Citation
 Liu, J; Yang, C; Simpson, C; Deryckere, D; Van Deusen, A; Miley, MJ; Kireev, D; Norris-Drouin, J; Sather, S; Hunter, D; Korboukh, VK; Patel, HS; Janzen, WP; Machius, M; Johnson, GL; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett 3:129-134 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM50384605
Synonyms:
CHEMBL2036798 | US9744172, Compound UNC00000465A
Type:
Small organic molecule
Emp. Form.:
C22H28N6
Mol. Mass.:
376.4979
SMILES:
NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NC4CCC4)nc23)CC1 |(61.71,-49.99,;62.75,-48.84,;62.28,-47.38,;63.31,-46.24,;64.82,-46.57,;65.85,-45.43,;65.37,-43.96,;66.28,-42.71,;65.37,-41.45,;65.85,-39.99,;67.35,-39.67,;67.83,-38.21,;66.8,-37.06,;65.29,-37.39,;64.82,-38.85,;63.9,-41.93,;62.56,-41.17,;61.23,-41.94,;61.23,-43.48,;59.9,-44.25,;58.56,-43.48,;58.17,-41.99,;56.68,-42.39,;57.08,-43.88,;62.56,-44.25,;63.9,-43.48,;65.3,-48.02,;64.26,-49.17,)|
Structure:
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