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TargetTyrosine-protein kinase receptor TYRO3
LigandBDBM50384597
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820661
IC50 2100±n/a nM
Citation Liu, JYang, CSimpson, CDeryckere, DVan Deusen, AMiley, MJKireev, DNorris-Drouin, JSather, SHunter, DKorboukh, VKPatel, HSJanzen, WPMachius, MJohnson, GLEarp, HSGraham, DKFrye, SVWang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase receptor TYRO3
Name:Tyrosine-protein kinase receptor TYRO3
Synonyms:TYRO3 | Tyrosine-protein kinase SKY | Tyrosine-protein kinase receptor TYRO3
Type:Protein
Mol. Mass.:96894.13
Organism:Homo sapiens (Human)
Description:Q06418
Residue:890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384597
NameBDBM50384597
Synonyms:CHEMBL2036633 | US9744172, Compound UNC00000486A
TypeSmall organic molecule
Emp. Form.C20H23F3N6
Mol. Mass.404.432
SMILESCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)C(F)(F)F |(-9.78,-29,;-8.45,-29.77,;-7.11,-29.01,;-7.11,-27.46,;-5.78,-26.69,;-4.45,-27.45,;-2.97,-26.97,;-2.06,-28.23,;-2.97,-29.48,;-2.49,-30.95,;-3.52,-32.09,;-5.03,-31.76,;-6.06,-32.9,;-5.59,-34.37,;-6.63,-35.51,;-4.09,-34.69,;-3.05,-33.55,;-4.45,-29.01,;-5.78,-29.78,;-2.5,-25.51,;-.99,-25.19,;-.51,-23.73,;-1.54,-22.58,;-3.06,-22.91,;-3.53,-24.37,;-1.07,-21.12,;.44,-20.8,;-2.1,-19.98,;-.31,-19.78,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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