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TargetTyrosine-protein kinase receptor TYRO3
LigandBDBM50384598
Substrate/Competitorn/a
Meas. Tech.ChEMBL_820661
IC50 120±n/a nM
Citation Liu, JYang, CSimpson, CDeryckere, DVan Deusen, AMiley, MJKireev, DNorris-Drouin, JSather, SHunter, DKorboukh, VKPatel, HSJanzen, WPMachius, MJohnson, GLEarp, HSGraham, DKFrye, SVWang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase receptor TYRO3
Name:Tyrosine-protein kinase receptor TYRO3
Synonyms:TYRO3 | Tyrosine-protein kinase SKY | Tyrosine-protein kinase receptor TYRO3
Type:Protein
Mol. Mass.:96894.13
Organism:Homo sapiens (Human)
Description:Q06418
Residue:890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384598
NameBDBM50384598
Synonyms:CHEMBL2036788 | US9744172, Compound UNC00000393A
TypeSmall organic molecule
Emp. Form.C25H28N6
Mol. Mass.412.53
SMILESCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)-c1ccccc1 |(2.22,-28.77,;3.55,-29.54,;4.89,-28.77,;4.89,-27.22,;6.22,-26.45,;7.55,-27.22,;9.03,-26.74,;9.94,-27.99,;9.03,-29.25,;9.5,-30.71,;8.47,-31.86,;6.96,-31.52,;5.94,-32.66,;6.41,-34.13,;5.37,-35.27,;7.91,-34.45,;8.95,-33.31,;7.55,-28.77,;6.22,-29.54,;9.5,-25.27,;11.01,-24.96,;11.49,-23.49,;10.45,-22.35,;8.94,-22.68,;8.47,-24.14,;10.92,-20.89,;12.43,-20.57,;12.91,-19.11,;11.87,-17.96,;10.36,-18.29,;9.89,-19.75,)|
Structure
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