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Target
Proto-oncogene tyrosine-protein kinase ROS
Ligand
BDBM50384726
Substrate
n/a
Meas. Tech.
ChEMBL_821034 (CHEMBL2039221)
IC50
5500±n/a nM
Citation
 Albaugh, P; Fan, Y; Mi, Y; Sun, F; Adrian, F; Li, N; Jia, Y; Sarkisova, Y; Kreusch, A; Hood, T; Lu, M; Liu, G; Huang, S; Liu, Z; Loren, J; Tuntland, T; Karanewsky, DS; Seidel, HM; Molteni, V Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett 3:140-145 (2012) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase ROS
Synonyms:
Proto-oncogene c-Ros | Proto-oncogene c-Ros-1 | ROS1_MOUSE | Receptor tyrosine kinase c-ros oncogene 1 | Ros | Ros-1 | Ros1 | c-Ros receptor tyrosine kinase
Type:
PROTEIN
Mol. Mass.:
261946.98
Organism:
Mus musculus
Description:
ChEMBL_821034
Residue:
2340
Sequence:
MKNICWLTLKLVKFVVLGCIIWISVAQSTVLSSCLTSCVTNLGRQLDSGTRYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGSYEEEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPGSWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFSEGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVYVCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPSGRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRVLPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSAWQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQESSFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFTVEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSSGRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTLFLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPGKRIISLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGVPGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKGFEGEDDEMVTLNSDDTMPVALMETKNQEGLNYMVLATKCSQGEGSYEGPLGPKELGSCDLKKDKKQPQADKDFCQEPQVAYGSPGLSEGLNYACLAHSEHGDVSE
  
Inhibitor
Name:
BDBM50384726
Synonyms:
CHEMBL2037208
Type:
Small organic molecule
Emp. Form.:
C27H19F3N4O2
Mol. Mass.:
488.4606
SMILES:
FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Structure:
Search PDB for entries with ligand similarity: