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TargetOxytocin receptor
LigandBDBM50384827
Substrate/Competitorn/a
Meas. Tech.ChEMBL_821172
Ki 39.81±n/a nM
Citation Borthwick, ADLiddle, JDavies, DEExall, AMHamlett, CHickey, DMMason, AMSmith, IENerozzi, FPeace, SPollard, DSollis, SLAllen, MJWoollard, PMPullen, MAWestfall, TDStanislaus, DJ Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency. J Med Chem55:783-96 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Oxytocin receptor
Name:Oxytocin receptor
Synonyms:OT-R | Oxytocin
Type:Enzyme Catalytic Domain
Mol. Mass.:42793.26
Organism:HEK293
Description:Oxytocin OXTR HEK293::B2R9L7
Residue:389
Sequence:
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACV
LLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAA
AEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVW
DANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGET
SASKKSNSSSFVLSHRSSSQRSCSQPSTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50384827
NameBDBM50384827
Synonyms:CHEMBL2035014
TypeSmall organic molecule
Emp. Form.C29H34F3N3O4
Mol. Mass.545.5932
SMILESCC(C)C[C@H]1N([C@@H](C(=O)NC(C)C)c2ccccc2OC(F)(F)F)C(=O)[C@H](NC1=O)C1Cc2ccccc2C1 |r|
Structure
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