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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50385123
Substrate
n/a
Meas. Tech.
ChEMBL_822931 (CHEMBL2038102)
EC50
3.2±n/a nM
Citation
 Kambe, T; Maruyama, T; Nakai, Y; Oida, H; Maruyama, T; Abe, N; Nishiura, A; Nakai, H; Toda, M Synthesis and evaluation of¿-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists. Bioorg Med Chem 20:3502-22 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_RAT | Prostanoid EP4 receptor | Ptger4
Type:
PROTEIN
Mol. Mass.:
53381.95
Organism:
Rattus norvegicus
Description:
ChEMBL_1290039
Residue:
488
Sequence:
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50385123
Synonyms:
CHEMBL2036313
Type:
Small organic molecule
Emp. Form.:
C27H30N2O4S2
Mol. Mass.:
510.668
SMILES:
O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Structure:
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