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TargetAdrenomedullin receptor, AM2; CALCRL/RAMP3
LigandBDBM50385309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_822728
Ki 590±n/a nM
Citation Bell, IMStump, CAGallicchio, SNStaas, DDZartman, CBMoore, ELSain, NUrban, MBruno, JGCalamari, AKemmerer, ALMosser, SDFandozzi, CWhite, RBZrada, MMSelnick, HGGraham, SLVacca, JPKane, SASalvatore, CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett22:3941-5 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adrenomedullin receptor, AM2; CALCRL/RAMP3
Name:Adrenomedullin receptor, AM2; CALCRL/RAMP3
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 822728
Components:This complex has 2 components.
Component 1
Name:Adrenomedullin receptor AM1; CALCRL/RAMP2
Synonyms:Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor
Type:Enzyme
Mol. Mass.:52931.38
Organism:Homo sapiens (Human)
Description:Q16602
Residue:461
Sequence:
MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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Component 2
Name:Receptor activity-modifying protein 3
Synonyms:CRLR activity-modifying protein 3 | Calcitonin-receptor-like receptor activity-modifying protein 3 | RAMP3
Type:PROTEIN
Mol. Mass.:16516.30
Organism:Homo sapiens (Human)
Description:EBI_104910
Residue:148
Sequence:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLS
EFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLI
PLIVIPVVLTVAMAGLVVWRSKRTDTLL
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BDBM50385309
NameBDBM50385309
Synonyms:CHEMBL2035983
TypeSmall organic molecule
Emp. Form.C31H30F2N6O3
Mol. Mass.572.6051
SMILESC[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure
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n/a