Reaction Details Report a problem with these data
Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM50385309
Substrate
n/a
Meas. Tech.
ChEMBL_822703 (CHEMBL2040020)
Ki
19±n/a nM
Citation
 Bell, IM; Stump, CA; Gallicchio, SN; Staas, DD; Zartman, CB; Moore, EL; Sain, N; Urban, M; Bruno, JG; Calamari, A; Kemmerer, AL; Mosser, SD; Fandozzi, C; White, RB; Zrada, MM; Selnick, HG; Graham, SL; Vacca, JP; Kane, SA; Salvatore, CA MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats. Bioorg Med Chem Lett 22:3941-5 (2012) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
CALRL_MOUSE | CGRP type 1 receptor | Calcitonin receptor-like receptor | Calcrl | Crlr
Type:
PROTEIN
Mol. Mass.:
53266.80
Organism:
Mus musculus
Description:
ChEMBL_822703
Residue:
463
Sequence:
MDKKHILCFLVLLPLNMALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQAEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHFQGLLVATIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDMQGYSHDCPTEHLNGKSIQDIENVALKSENMYDLVM
  
Inhibitor
Name:
BDBM50385309
Synonyms:
CHEMBL2035983
Type:
Small organic molecule
Emp. Form.:
C31H30F2N6O3
Mol. Mass.:
572.6051
SMILES:
C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1 |r|
Structure:
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