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TargetPA/PB1
LigandBDBM50385536
Substrate/Competitorn/a
Meas. Tech.ChEMBL_823246
IC50 6500±n/a nM
Citation Singh, SBTomassini, JE Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem66:5504-16 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
PA/PB1
Name:PA/PB1
Synonyms:Hepatitis C virus polyprotein | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2
Type:PROTEIN
Mol. Mass.:82573.84
Organism:Hepatitis C virus
Description:ChEMBL_64976
Residue:716
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQ
EMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNG
YIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNM
KKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50385536
NameBDBM50385536
Synonyms:CHEMBL2040608
TypeSmall organic molecule
Emp. Form.C18H13FN2O3
Mol. Mass.324.3058
SMILESOn1c(=O)c(=Cc2ccccc2)[nH]c(=Cc2ccc(F)cc2)c1=O |w:14.15,5.5|
Structure
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n/a