Target
Serine/threonine-protein kinase Nek2
Ligand
BDBM50385928
Substrate
n/a
Meas. Tech.
ChEMBL_824216 (CHEMBL2044151)
IC50
93±n/a nM
Citation
 Innocenti, PCheung, KMSolanki, SMas-Droux, CRowan, FYeoh, SBoxall, KWestlake, MPickard, LHardy, TBaxter, JEAherne, GWBayliss, RFry, AMHoelder, S Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem 55:3228-41 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek2
Synonyms:
NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1
Type:
Enzyme
Mol. Mass.:
51776.96
Organism:
Homo sapiens (Human)
Description:
P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM50385928
Synonyms:
CHEMBL2042038
Type:
Small organic molecule
Emp. Form.:
C31H31F3N4O2S
Mol. Mass.:
580.664
SMILES:
CC(Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1ccc(CN2CCCCC2)s1)c1ccccc1C(F)(F)F
Structure:
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