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Target
Nitric oxide synthase, inducible
Ligand
BDBM50386178
Substrate
n/a
Meas. Tech.
ChEMBL_824673 (CHEMBL2045838)
Ki
1.8±n/a nM
Citation
 Pozo-Rodrigálvarez, A; Gradillas, A; Serrano, J; Fernández, AP; Martínez-Murillo, R; Pérez-Castells, J New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. Eur J Med Chem 54:439-46 (2012) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, inducible
Synonyms:
NOS2_RAT | Nos2
Type:
PROTEIN
Mol. Mass.:
130642.55
Organism:
Rattus norvegicus
Description:
ChEMBL_976228
Residue:
1147
Sequence:
MACPWKFLFRVKSYQGDLKEEKDINNNVEKTPGAIPSPTTQDDPKSHKHQNGFPQFLTGTAQNVPESLDKLHVTPSTRPQHVRIKNWGNGEIFHDTLHHKATSDISCKSKLCMGSIMNSKSLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTASEMFQHICRHILYATNSGNIRSAITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRGDPATLEFTQLCIDLGWKPRYGRFDVLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINAAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQDEKLRPRRREIRFTVLVKAVFFASVLMRKVMASRVRATVLFATETGKSEALARDLAALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRSKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCSSPDQTVCLEVLDESGSYWVKDKRLPPCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMVRKGVLFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGNTLEEPKGTRL
  
Inhibitor
Name:
BDBM50386178
Synonyms:
CHEMBL1800346 | ONO-1714
Type:
Small organic molecule
Emp. Form.:
C7H11ClN2
Mol. Mass.:
158.629
SMILES:
C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12 |r,c:4|
Structure:
Search PDB for entries with ligand similarity: