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Target
Proteinase-activated receptor 1
Ligand
BDBM50386401
Substrate
n/a
Meas. Tech.
ChEMBL_826811 (CHEMBL2051432)
IC50
2280±n/a nM
Citation
 Dockendorff, C; Aisiku, O; Verplank, L; Dilks, JR; Smith, DA; Gunnink, SF; Dowal, L; Negri, J; Palmer, M; Macpherson, L; Schreiber, SL; Flaumenhaft, R Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. ACS Med Chem Lett 3:232-237 (2012) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50386401
Synonyms:
CHEMBL2049116
Type:
Small organic molecule
Emp. Form.:
C17H16BrClN2O2
Mol. Mass.:
395.678
SMILES:
CCCC(=O)Nc1cccc(NC(=O)c2c(Cl)cccc2Br)c1
Structure:
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