Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50386655
Substrate
n/a
Meas. Tech.
ChEMBL_826835 (CHEMBL2051552)
Ki
47±n/a nM
Citation
 Mikami, S; Kitamura, S; Negoro, N; Sasaki, S; Suzuki, M; Tsujihata, Y; Miyazaki, T; Ito, R; Suzuki, N; Miyazaki, J; Santou, T; Kanzaki, N; Funami, M; Tanaka, T; Yasuma, T; Momose, Y Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem 55:3756-76 (2012) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50386655
Synonyms:
CHEMBL2048613
Type:
Small organic molecule
Emp. Form.:
C25H26O4
Mol. Mass.:
390.4715
SMILES:
COc1ccc(COc2ccc(CCC(O)=O)cc2)cc1-c1c(C)cccc1C |(-8.08,-1.71,;-8.07,-3.25,;-6.73,-4.01,;-5.41,-3.23,;-4.06,-4,;-4.06,-5.54,;-2.72,-6.3,;-1.39,-5.53,;-.05,-6.3,;-.05,-7.83,;1.28,-8.6,;2.61,-7.83,;3.95,-8.59,;5.28,-7.81,;6.62,-8.58,;6.63,-10.12,;7.95,-7.8,;2.6,-6.28,;1.27,-5.52,;-5.39,-6.31,;-6.72,-5.54,;-8.05,-6.32,;-9.38,-5.55,;-9.39,-4.01,;-10.71,-6.32,;-10.71,-7.87,;-9.38,-8.64,;-8.04,-7.87,;-6.71,-8.63,)|
Structure:
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