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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50386775
Substrate
n/a
Meas. Tech.
ChEMBL_826735 (CHEMBL2051182)
IC50
95±n/a nM
Citation
 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem 55:3837-51 (2012) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50386775
Synonyms:
CHEMBL2046916
Type:
Small organic molecule
Emp. Form.:
C20H19ClN5O5P
Mol. Mass.:
475.822
SMILES:
CNc1nc2nc(-c3ccc(cc3)P(O)(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1
Structure:
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