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Target
Ubiquitin-like modifier-activating enzyme 1
Ligand
BDBM50387034
Substrate
n/a
Meas. Tech.
ChEMBL_827633 (CHEMBL2050672)
IC50
35000±n/a nM
Citation
 Yamanokuchi, R; Imada, K; Miyazaki, M; Kato, H; Watanabe, T; Fujimuro, M; Saeki, Y; Yoshinaga, S; Terasawa, H; Iwasaki, N; Rotinsulu, H; Losung, F; Mangindaan, RE; Namikoshi, M; de Voogd, NJ; Yokosawa, H; Tsukamoto, S Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus. Bioorg Med Chem 20:4437-42 (2012) [PubMed]  Article 
Target
Name:
Ubiquitin-like modifier-activating enzyme 1
Synonyms:
A1S9T | UBA1 | UBA1_HUMAN | UBE1
Type:
PROTEIN
Mol. Mass.:
117834.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_827630
Residue:
1058
Sequence:
MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
  
Inhibitor
Name:
BDBM50387034
Synonyms:
CHEMBL2046769
Type:
Small organic molecule
Emp. Form.:
C16H16N4O3
Mol. Mass.:
312.3232
SMILES:
OC(=O)[C@@H]1Cc2c([nH]c3ccc(O)cc23)[C@H](Cc2cnc[nH]2)N1 |r|
Structure:
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