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Target
Histamine H4 receptor
Ligand
BDBM50387465
Substrate
n/a
Meas. Tech.
ChEMBL_828300 (CHEMBL2050319)
Ki
251.19±n/a nM
Citation
 Engelhardt, H; de Esch, IJ; Kuhn, D; Smits, RA; Zuiderveld, OP; Dobler, J; Mayer, M; Lips, S; Arnhof, H; Scharn, D; Haaksma, EE; Leurs, R Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands. Eur J Med Chem 54:660-8 (2012) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50387465
Synonyms:
CHEMBL2047472
Type:
Small organic molecule
Emp. Form.:
C14H15ClFN3O
Mol. Mass.:
295.74
SMILES:
CN[C@@H]1CCN(C1)C(=O)c1cc2cc(Cl)cc(F)c2[nH]1 |r|
Structure:
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