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Target
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Ligand
BDBM26613
Substrate
n/a
Meas. Tech.
ChEMBL_829771 (CHEMBL2061290)
IC50
10000±n/a nM
Citation
 Mak, LH; Knott, J; Scott, KA; Scott, C; Whyte, GF; Ye, Y; Mann, DJ; Ces, O; Stivers, J; Woscholski, R Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. Bioorg Med Chem 20:4371-6 (2012) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms:
MMAC1 | Mutated in multiple advanced cancers 1 | PTEN | PTEN_HUMAN | Phosphatase and tensin homolog | TEP1
Type:
PROTEIN
Mol. Mass.:
47164.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_829771
Residue:
403
Sequence:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
  
Inhibitor
Name:
BDBM26613
Synonyms:
(2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-enoic acid | Compound 13778
Type:
Small organic molecule
Emp. Form.:
C9H9O5Sb
Mol. Mass.:
318.92
SMILES:
OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Structure:
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