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Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50388772
Substrate
n/a
Meas. Tech.
ChEMBL_830881 (CHEMBL2065430)
EC50
650±n/a nM
Citation
 Pellicciari, R; Gioiello, A; Sabbatini, P; Venturoni, F; Nuti, R; Colliva, C; Rizzo, G; Adorini, L; Pruzanski, M; Roda, A; Macchiarulo, A Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators. ACS Med Chem Lett 3:273-277 (2012) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50388772
Synonyms:
CHEMBL2062554
Type:
Small organic molecule
Emp. Form.:
C26H43O5
Mol. Mass.:
435.6172
SMILES:
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3C[C@H](O)[C@H]([C@H](C)CCC([O-])=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r|
Structure:
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