Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50258656
Substrate
n/a
Meas. Tech.
ChEMBL_832795 (CHEMBL2067891)
EC50
1200±n/a nM
Citation
 Melancon, BJ; Hopkins, CR; Wood, MR; Emmitte, KA; Niswender, CM; Christopoulos, A; Conn, PJ; Lindsley, CW Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem 55:1445-64 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50258656
Synonyms:
1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL466253 | VU0238429 | cid_42633508
Type:
Small organic molecule
Emp. Form.:
C17H12F3NO4
Mol. Mass.:
351.2767
SMILES:
COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
Structure:
Search PDB for entries with ligand similarity: