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Target
Metabotropic glutamate receptor 6
Ligand
BDBM50388941
Substrate
n/a
Meas. Tech.
ChEMBL_832800 (CHEMBL2066313)
EC50
>30000±n/a nM
Citation
 Melancon, BJ; Hopkins, CR; Wood, MR; Emmitte, KA; Niswender, CM; Christopoulos, A; Conn, PJ; Lindsley, CW Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem 55:1445-64 (2012) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
95479.26
Organism:
Homo sapiens (Human)
Description:
metabotropic glutamate 6 GRM6 HUMAN::O15303
Residue:
877
Sequence:
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
  
Inhibitor
Name:
BDBM50388941
Synonyms:
CHEMBL2063423
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3
Mol. Mass.:
295.2927
SMILES:
O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccn1 |r|
Structure:
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