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TargetMatrix Metalloproteinase-8 (MMP-8)
LigandBDBM50389100
Substrate/Competitorn/a
Meas. Tech.ChEMBL_832926
IC50 0.02±n/a nM
Citation Hugenberg, VBreyholz, HJRiemann, BHermann, SSchober, OSchäfers, MGangadharmath, UMocharla, VKolb, HWalsh, JZhang, WKopka, KWagner, S A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem55:4714-27 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix Metalloproteinase-8 (MMP-8)
Name:Matrix Metalloproteinase-8 (MMP-8)
Synonyms:Collagenase 2 | MMP-8 | MMP8 | Matrix metalloproteinase-8 | Neutrophil collagenase | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (human)
Description:n/a
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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  Blast E-value cutoff:
BDBM50389100
n/a
NameBDBM50389100
Synonyms:CHEMBL2064547
TypeSmall organic molecule
Emp. Form.C17H24FN5O5S
Mol. Mass.429.466
SMILESCOc1ccc(cc1)S(=O)(=O)N(Cc1cn(CCF)nn1)[C@H](C(C)C)C(=O)NO |r|
Structure
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